Deadly Common Drug Combinations
Overview
Prescription medications and over-the-counter drugs are often combined with other medicines or alcohol without knowing the risks. This can lead to serious side effects and even death in some cases. It’s essential to be aware of the dangers associated with drug combinations and take steps to avoid them whenever possible.

THINKING ABOUT TREATMENT?
Call Us Anytime: 1-866-754-0180
What Is Polysubstance Abuse?
The Dangers of Alcohol and Opioids Combinations
Drug overdose and death are severe complications of polydrug use, including alcohol and opiates. Alcohol use and prescription opioid abuse can lead to serious drug interactions. 5
Alcohol and Opioids Overdose Symptoms
Alcohol and Benzodiazepines Combination
Benzodiazepines are depressant drugs that can lead to adverse drug interactions when combined with alcohol. 4
Alcohol and Benzodiazepines Overdose Symptoms
Overdose symptoms of these deadly drug combos can include vomiting, diarrhea, unresponsiveness, limp body, seizures, slow pulse, and difficulty breathing. 7
The Dangers of Alcohol and Benzodiazepines Combination
Heroin and Cocaine Combination - Speedballs
When an individual mixes heroin and cocaine or amphetamines, it is sometimes called speedballing. The drug interactions between these substances can have devastating effects.
Speedballs Overdose Symptoms
The overdose symptoms of speedballing can include loss of consciousness, pale face, blue fingernails, choking, hallucinations, difficulty breathing, paranoia, seizures, loss of balance, and more. If you or someone you love is experiencing symptoms of an overdose, call emergency services immediately. You should also place them on their side to keep their airway open if possible. Do not try to make a person vomit, give them food, or offer anything to drink. 7
The Dangers of Heroin and Cocaine Combination
Other Deadly Drug Combinations
Cocaine and Alcoho
Deadly Prescription Drug Combinations
Club Drugs
You may be wondering, what are club drugs? Club drugs are psychoactive substances that stimulate the central nervous system. If individuals are using club drugs, they may experience behavior, awareness, and mood changes. As you may have inferred from the name, young adults commonly use club drugs at parties, nightclubs, concerts, etc. Well-known club drugs include MDMA, liquid ecstasy, ketamine, Rohypnol, methamphetamine, and LSD. Club drugs are sometimes used as date rape drugs. Deadly drug combos can be created when mixed with alcohol or another drug. 10
Marijuana and Other Drugs
Treatment for Polysubstance Abuse at Concise Recovery

Say no to addiction and avoid deadly common drug combinations! At Concise Recovery, overcoming addiction is possible and achievable. The following sections will discuss polydrug abuse treatment options and what to expect at Concise Recovery.
Our Treatment and Recovery Options for Polydrug Abuse
Concise Recovery offers multiple treatment formats for individuals struggling to overcome addiction. Whether you need detoxification, residential inpatient, partial day treatment, outpatient programming, or sober living, Concise Recovery is here to help. Concise Recovery also provides dual diagnosis treatment for addiction, mental health, and trauma.
What To Expect
If you choose Concise Recovery, you will embark upon a physical and mental healing journey. The team at Concise Recovery creates individualized treatment plans to empower each client to live a fulfilling and healthy life. Your treatment program will be specifically designed to meet your unique needs. Skilled therapists, nurses, doctors, and addiction professionals come together to provide high-quality therapeutic care.
Getting Help
Contact our friendly concierge team today to enroll in world-class treatment services at Concise Recovery!
Resources
- https://www.lhsfna.org/accidental-lethal-drug-mixes-more-common/
- https://ncapda.org/parents/drug-overdose/?gclid=Cj0KCQjwr-SSBhC9ARIsANhzu17FKizrslz_b3JghJ3C4H95AH3QUjFJb_7yNlsKkupsC7UA388WLagaAlEfEALw_wcB
- https://www.cdc.gov/stopoverdose/polysubstance-use/index.html#:~:text=The%20use%20of%20more%20than,period%2C%20either%20intentionally%20or%20unintentionally.
- https://www.sahealth.sa.gov.au/wps/wcm/connect/public+content/sa+health+internet/conditions/drugs/dangers+of+mixing+drugs
- https://www.cdc.gov/media/releases/2019/p0611-people-opioids-drink.html
- https://www.niaaa.nih.gov/publications/brochures-and-fact-sheets/understanding-dangers-of-alcohol-overdose
- https://www.betterhealth.vic.gov.au/health/healthyliving/drug-overdose
- https://www.sahealth.sa.gov.au/wps/wcm/connect/7592c9004f50b005aba6ef330cda8a00/Risks+associated+with+benzodiazepines+%2800506%29+2017.pdf?MOD=AJPERES&CACHEID=ROOTWORKSPACE-7592c9004f50b005aba6ef330cda8a00-nKPRdFk
- https://nida.nih.gov/publications/research-reports/misuse-prescription-drugs/it-safe-to-use-prescription-drugs-in-combination-other-medications
- https://medlineplus.gov/clubdrugs.html
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055953/#:~:text=Additive%20effects%20can%20occur%20with,e.g.%2C%20tachycardia%2C%20confusion).