How Long Does Lisinopril Stay in Your System?

Find out what lisinopril is used for, its effects, and treatment methods for lisinopril addiction.

How Long Does It Take for Lisinopril to Work?

Lisinopril medication is used to treat high blood pressure, improve overall blood flow, and reduce heart attack symptoms. It’s been in use for the last thirty years and is one of the most commonly prescribed medicines for the aforementioned conditions. But, how long does lisinopril stay in your system?

How Long Does Lisinopril Stay in Your System


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Lisinopril Half-Life

Lisinopril is known to have a longer half-life than its alternatives, with a half-life of 12.6 hours. Plus, lisinopril isn’t metabolized by the body—when excreted, its chemical form is unchanged and easily detectable. The drug doesn’t bind to bodily chemicals, which reduces how much is absorbed once it’s ingested.1

How Long Does Lisinopril Stay in Lab Tests?

Lisinopril is detectable up to five days after last use. Regular use of the drug can create a stabilized environment where the drug is excreted at the same rate it’s being absorbed into the body. It’s typically taken twice within twenty-four hours to achieve and maintain this stabilization. The drug may be detectable for longer than average due to repeated use.1

Type of Tests

Answering the question of how long does lisinopril stay in your system is dependent on the type of test used to detect it. For example, common tests, such as urine, blood, and saliva, will show the drug for days to weeks after last use; however, hair tests can be used to detect the drug months after last use. Generally, this is true for any abused substance.2
Tests for this medication are usually conducted to discover what medications are in a patient’s system, allergies, etc. The lisinopril half-life makes it so that the drug can be changed or stopped in a fairly short amount of time. That way, negative lisinopril side effects can be quickly managed.

Withdrawal Symptoms

It’s worth noting that lisinopril abuse doesn’t have the same withdrawal phase as more commonly abused substances such as alcohol. Studies show that many of the symptoms associated with suddenly quitting lisinopril center around worsened heart conditions and blood pressure. Another symptom of stopping this medication is the famed lisinopril cough that can last years after final use.


A common medical disclaimer is that any averages and side effects vary from person to person. This is largely due to the effect that metabolism plays in filtering out drugs. Lisinopril, however, is not metabolized by the body but is instead excreted via the liver. This limits the effect that metabolism, high or low, has on the substance.

Lisinopril Usage

Lisinopril therapeutic use happens only with a prescription. While the strength of the drug may vary, it’s commonly taken a max of twice per day. Because the lisinopril half-life is twelve hours, taking it twice a day allows the body to be under its effects constantly.

If a person accidentally takes lisinopril twice in one sitting, they should skip their next dose and resume normal dosage the following day. Lisinopril side effects can manifest after first use. If someone has adverse reactions to the drug, they should consult their doctor. It is worth noting that lisinopril use during pregnancy is not suggested.

How Long Does Lisinopril Stay in Your System?

Because lisinopril is metabolized and binds to only a few enzymes in the body, it isn’t detectable in the system for more than a few days at a time—with the exception of hair tests. This means a doctor is able to start prescribing medication for other illnesses, detox a patient on lisinopril, and more in a fairly short amount of time.

Treatment of Lisinopril Drug Abuse

Lisinopril doesn’t have the same addictive capabilities as other abused substances. Nevertheless, a patient may form a psychological connection to and craving for the drug. In this case, the following are recommended treatment options should addiction occur.

How Long Does Lisinopril Stay in Your System

Cognitive-Behavioral Therapy

Cognitive-behavioral therapy, also known as CBT, is used to change a person’s everyday habits and thoughts. Over time, a person gains a deeper perspective of their actions and control over them. This process takes time, but its effects can subsist for years after the last session. CBT also helps teach healthy coping mechanisms for lisinopril withdrawal symptoms and cravings.3

Dialectical Behavior Therapy

Also known as DBT, dialectical behavior therapy is a subset of CBT in which a person is logically guided through their illogical behaviors. In this way, a person is able to realize their own logical shortcomings and the impact it has on their substance dependency.4

Group Therapy

Group therapy is a form of talk therapy where individuals who struggle with addiction can speak freely with like-minded people. It also helps give perspective on what to expect in long-term recovery. All in all, group therapy is a great option for stopping lisinopril and other substances.5

Medication-Assisted Treatment

Medication-assisted treatment, or MAT, helps ease the more severe forms of drug withdrawal and replenish vital nutrients. Plus, the side effects of stopping lisinopril can be counteracted with proper medical care.6

Can You Detox from Lisinopril Faster?

How long does lisinopril stay in your system, and can you detox fast are commonly asked questions. The answer to both is that it varies because lisinopril’s half-life isn’t decided by metabolism—stopping lisinopril does have side effects. Here’s what you need to know about detox:7


Genetics play a factor in how well the body absorbs medicine, but because lisinopril is minimally absorbed in the body, the effects of genetics is limited. That said, genetics do play a big role in how easily a person can form an addiction. In addition, lisinopril withdrawal symptoms may also be more severe in a person genetically inclined to addiction.


Individuals with certain eye conditions, heart problems, and blood pressure complications may take longer to detox from lisinopril. Nonetheless, the side effects of stopping lisinopril can be managed with treatment.

Drug Use patterns

Infrequent use of the drug will detox far quicker than with regular use. The danger of lisinopril, and other drugs, is amplified when taken illegally and abused. Mixing the substance with alcohol, other pharmacological medications, and various drugs can cause adverse effects. Thus, because lisinopril is filtered out solely by the liver, mixing other drugs can cause severe strain, leading to liver failure.

Learn More with Concise Recovery

If you find yourself asking how long does lisinopril stay in your system, lisinopril half-life, and lisinopril side effects, then chances are you or someone you know is suffering from addiction. Get the help needed to combat addiction and withdrawal symptoms of lisinopril and other substance abuse. Concise Recovery is here to guide and ease the recovery process. Don’t wait. Reach out today and get help.