How Long Does Trazodone Stay in Your System?

How long does trazodone stay in your system? Read on to learn how Trazodone can affect the body and how to pursue treatment.

What is Trazodone?

Although trazodone is designed to treat depression, studies have shown that becoming dependent on its use can happen easily. Recovering from trazodone is possible, and recovery can be easier than you or your loved ones think.

How Long Does Trazodone Stay in Your System

Trazodone is an antidepressant drug designed to improve users’ mood, energy, and appetite. In addition, it can lessen a person’s anxiety levels and help check conditions such as insomnia which commonly accompanies depression. It also works for schizophrenia, sleep difficulties, and dependence on substances such as alcohol.1


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How Does Trazodone Work?

Chemically, trazodone helps refill the brain’s serotonin, a neurotransmitter that regulates the body’s emotions. Experts categorize trazodone as a serotonin antagonist reuptake inhibitor (SARI).
Drugs in this category help prevent neurons from using serotonin when released into the central nervous system. This way, serotonin will be used in the way the body needs it to be to give the brain the right energy and excitement.
Trazodone can still be detected in the blood for two to three days after use, and has a five to thirteen hour window for its half-life.2

How Long Does Trazodone Stay in Your System?

Trazodone can linger in an adult body system for two to three days on a single dose. However, the drug may still be found in various parts and fluids of the body. Unlike other antidepressants, trazodone doesn’t easily show up in typical drug tests. As such, there are different ways to test for trazodone. These can include:

Blood Test

This is the most common test type and can generate the most accurate results, with precision levels reaching 97%. Trazodone can be detected during a blood test for up to three days after the last dose taken.

Urine Test

The trazodone urine drug screen is another method for testing for trazodone presence, and it is usually just as accurate as a blood test. A benefit of the urine test is that the drug can easily be detected in the urine. Trazodone stays detectable much longer in the urine and can still be detected up to twenty-six days after the last use.

Saliva Test

Although not as common, a saliva test is quite easy to conduct, as all labs need is a saliva swab. However, it isn’t the most accurate way to detect trazodone and will only be detectable between from a few hours after usage to a day or so later.

Hair Test

Hair has the longest detection period, as it can show trazodone on drug tests some for up to ninety days after the last dose. Hair tests, however, are less accurate than urine tests and are more expensive.3

Elements That Impact Trazodone Abuse

Trazodone abuse is not overly common, but is still prevalent enough in some populations. A few elements will determine if a test will flag for trazodone abuse in these users. These include:

Trazodone Use History

The nature of a person’s use will heavily influence the chances of detecting trazodone on a drug test. For example, if the person has used trazodone for a lengthy period and has taken it in significant doses, the drug will last longer and easily be detected.

Use of Other Substances

Frequent use of other substances such as other drugs and alcohol decreases the rate at which the body processes and excretes trazodone. As such, trazodone will remain detected for much longer on tests.


The rate at which your body metabolizes substances will affect whether there will still be remains of trazodone after a significant period of time. However, a person’s age, genetics, and weight can all significantly affect their metabolism.

Type of Drug Test

The various types of tests vary in their accuracy and ability to detect trazodone after some time. For instance, a trazodone urine drug screen can detect the drug up to almost a month after the last use, while a hair test can detect it for up to three months.

Factors That Affect How Long Trazodone Will Stay in Your System

Many varying factors can determine the length of time that trazodone will linger in a person’s body system. Some of these include a person’s:


Many studies show that older adults’ bodies don’t metabolize drugs as well as their younger counterparts. This means that these older individuals will have trazodone stay much longer in the body, impacting the drug’s side effects.


Experiments show that males are likely to have trazodone stay for longer periods in their bodies than females. The study further revealed that the concentration is highest in elderly males.

Liver and Kidney Function

The liver and kidney assist in purifying the body of wastes from substances such as drugs. Therefore, how effective the liver and kidney are at processing these materials will determine how long trazodone will stay. If someone has liver or kidney disease, it will delay the purification of the drug from the body.

Weight and Metabolism

Another factor that influences the half-life of trazodone in the body is a person’s weight. Weight gain, in most cases, decreases a person’s metabolism, meaning the body will process the drug slower.

Trazodone Use Specifics

The frequency of using a trazodone antidepressant dose can affect its persistence in the body. If a person uses the drug frequently and for a long period, it will stay for longer in the body as well.4

Risks Associated with Trazodone

While trazodone can be beneficial for many patients, abusing it can lead to a few complications.


Statistics show that abusing trazodone is not common, but it’s possible, especially if used without a physician’s prescription. Therefore, it is best to get a doctor to prescribe the drug and to stick with the assigned dosage in order to prevent possible trazodone abuse.


Because of its ability to help with depression symptoms, trazodone abuse and dependence may quickly materialize. When this is the case, people suffering from dependency find it difficult to wean themselves of its use. If they do so, it can cause withdrawal symptoms.
If you or a loved one face this, working with specialists is the best way to safely wean off of trazodone usage and its side effects. Withdrawal symptoms from trazodone include headache, sadness, and fatigue, which may persist for a while after stopping.

Serotonin Syndrome

Trazodone boosts the supply of serotonin in the brain, but at times, there may be exceedingly high levels of the chemical, especially in cases of trazodone abuse. This is called serotonin syndrome, and symptoms include unnecessary agitation, high blood pressure, rapid heart rate, confusion, insomnia, and sometimes results in death.

Treatment of Improper Use of Trazodone at Concise Recovery

Treatment of Improper Use of Trazodone

While Trazodone helps many people for who it is prescribed for, using it inappropriately may cause your brain and body damage. Thus, if there are cases of such improper use, it’s important to seek help immediately. While there are several places you can look to for adequate help, Concise Recovery is one of the best and we will be here to help you every step of the way. Available treatment options will be detailed below.

Detoxing with Concise Recovery

Detoxification is often associated with discomfort, but Concise Recovery can change that. With the best facilities and staffing from leading experts, those who need help with detox can go through a largely painless trazodone detox process.

Rehabilitation and Therapy

Concise Recovery’s trazodone addiction treatment includes a top-notch rehabilitation program for inpatient and outpatient care, whether within our centers or at home. There are also many different types of therapy services available.

Getting Help

If you or a loved one have a problem dealing with trazodone addiction, using Concise Recovery’s treatment facilities is one of the best ways to manage it. If you want help dealing with trazodone substance abuse, consider starting with any type of treatment at Concise Recovery today.